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Cowden's disease--a report on the first case in Korea and literature review.

Lee, H R; Moon, Y S; Yeom, C H; Kim, K W; Chun, J Y; Kim, H K; Choi, H S; Kim, D K; Chung, T S.
J Korean Med Sci; 12(6): 570-5, 1997 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9443100
Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 32-year-old man with oral mucosal papillomatosis and plantar hyperkeratosis as a definite case of Cowden's disease according to the criteria proposed by Salem and Steck. The patient also had a thyroid mass and numerous gastrointestinal polyps endoscopically. Histologically the polyps were hamartomatous or hyperplastic polyps. The oral papillary lesions were fibroepithelial polyps and the thyroid mass was a follicular adenoma. We review the literature on this entity and summarize the pertinent findings. To the best of our knowledge, this is the first documented case of Cowden's disease in a Korean.
Selo DaSilva