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Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae.

Mendes, Ana Luisa Gomes; Joaquim, Heloísa Di Matteo; Zamae, Mara Inês Stefanini; Assis, Ramon Meira; Peixoto, Jéssica Renata de Moura; de Araújo, Margarida Maria Gomes; Guedes, Antônio Carlos Martins; Oliveira, Edward José; Magalhães, Vanessa Peruhype; Pascoal-Xavier, Marcelo Antônio.
Mem Inst Oswaldo Cruz; 115: e190324, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32130367

BACKGROUND:

Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflammasome has assumed a relevant role in the inflammatory response against microbiological agents. However, the involvement of inflammasome in leprosy remains poorly understood.

OBJECTIVES:

The aim is to associate biomarkers of inflammasome with the different immunopathological forms of leprosy.

METHODS:

We performed an observational, cross-sectional, and comparative study of the immunophenotypic expression of inflammasome-associated proteins in immunopathological forms of leprosy of 99 skin lesion samples by immunohistochemistry. The intensity and percentage of NLRP3, Caspase-1, Caspases-4/5, interleukin-1ß and interleukin-18 immunoreactivities in the inflammatory infiltrate of skin biopsies were evaluated.

FINDINGS:

Strong expression of NLRP3 and inflammatory Caspases-4/5 were observed in lepromatous leprosy (lepromatous pole). In addition, were observed low expression of caspase-1, interleukin-1ß, and interleukin-18 in tuberculoid and lepromatous leprosy. The interpolar or borderline form showed immunophenotype predominantly similar to the lepromatous pole. MAIN

CONCLUSIONS:

Our results demonstrate that the NLRP3 inflammasome is inactive in leprosy, suggesting immune evasion of M. leprae.
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