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Roden, Dan M; McLeod, Howard L; Relling, Mary V; Williams, Marc S; Mensah, George A; Peterson, Josh F; Van Driest, Sara L.
Lancet; 394(10197): 521-532, 2019 08 10.
Artigo em Inglês | MEDLINE | ID: mdl-31395440
Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy-the topic addressed here-is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, and ongoing efforts to implement pharmacogenetics in clinical practice.
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