Your browser doesn't support javascript.

Biblioteca Virtual em Saúde

Brasil

Home > Pesquisa > ()
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives.

Santiago, Natália N; de Alcântara, Giulianna P; da Costa, Juliana Silva; Carvalho, Samir A; Barbosa, Juliana M C; Salomão, Kelly; de Castro, Solange L; Pereira, Henrique M G; da Silva, Edson F.
Med Chem; 2019 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-31309899

BACKGROUND:

Approximately 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die of complications linked to this disease.

METHOD:

This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol and nitrofurazone.

RESULT/DISCUSSION:

The compounds were evaluated for their in vitro activity against bloodstream trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells.

CONCLUSION:

Among these hydrazonoyl derivatives, we identified the derivative (4) that showed trypanocidal activity (IC50/24 h = 15.0 µM) similar to Bz, the standard drug, and low toxicity to mammalian cells, reaching a SI value of 18.7.
Selo DaSilva