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Mesothelin, Calretinin, and Megakaryocyte Potentiating Factor as Biomarkers of Malignant Pleural Mesothelioma.

Jiménez-Ramírez, Carmina; Casjens, Swaantje; Juárez-Pérez, Cuauhtémoc Arturo; Raiko, Irina; Del Razo, Luz M; Taeger, Dirk; Calderón-Aranda, Emma S; Rihs, Hans-Peter; Acosta-Saavedra, Leonor Concepción; Weber, Daniel Gilbert; Cabello-López, Alejandro; Pesch, Beate; Ochoa-Vázquez, María Dolores; Burek, Katarzyna; Torre-Bouscoulet, Luis; Pérez-Padilla, José Rogelio; García-Bazan, Erik Marco; Brüning, Thomas; Johnen, Georg; Aguilar-Madrid, Guadalupe.
Lung; 197(5): 641-649, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31267149


Malignant pleural mesothelioma (MPM) is a highly lethal cancer caused by exposure to asbestos. Currently, the diagnosis is a challenge, carried out by means of invasive methods of limited sensitivity. This is a case-control study to evaluate the individual and combined performance of minimally invasive biomarkers for the diagnosis of MPM.


A study of 166 incident cases of MPM and 378 population controls of Mestizo-Mexican ethnicity was conducted. Mesothelin, calretinin, and megakaryocyte potentiating factor (MPF) were quantified in plasma by ELISA. The samples were collected from 2011 to 2016.


Based on ROC analysis and a preset specificity of 95%, the combination of the three biomarkers reached an AUC of 0.944 and a sensitivity of 82% in men. In women, an AUC of 0.937 and a sensitivity of 87% were reached. In nonconditional logistic regression models, the adjusted ORs in men were 7.92 (95% CI 3.02-20.78) for mesothelin, 20.44 (95% CI 8.90-46.94) for calretinin, and 4.37 (95% CI 1.60-11.94) for MPF. The ORs for women were 28.89 (95% CI 7.32-113.99), 17.89 (95% CI 3.93-81.49), and 2.77 (95% CI 0.47-16.21), respectively.


To our knowledge, this is the first study evaluating a combination of mesothelin, calretinin, and MPF, and demonstrating a sex effect for calretinin. The biomarker panel showed a good performance in a Mestizo-Mexican population, with high sensitivity and specificity for the diagnosis of MPM.
Selo DaSilva