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Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.

Dewarrat, Natacha; Kaiser, Julie; Baud, David; Alberio, Lorenzo; Gavillet, Mathilde.
Acta Haematol; : 1-4, 2019 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-31167179
This original report describes the management of a pregnant woman with congenital erythrocytosis (Chuvash polycythaemia) and reviews the scarce data available in the literature. Therapy consisted of low-dose aspirin and phlebotomies to maintain haematocrit <50% while monitoring iron stores to avoid severe deficiency detrimental to the foetus. Despite normal initial foetal growth, the pregnancy was complicated by preterm birth due to chorioamnionitis. The placenta showed no signs of thrombotic events. The published reports cover 13 pregnancies in 8 patients, showing 1 first-trimester miscarriage, 5 infants with intrauterine growth restriction and/or preterm birth and 1 maternal thrombotic event. These cases were managed with phlebotomies, low-dose aspirin and/or low-molecular-weight heparin, although inconsistently.
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