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Acalabrutinib for mantle cell lymphoma.

Witzig, Thomas E; Inwards, David.
Blood; 133(24): 2570-2574, 2019 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-30967367
Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. MCL patients typically live for years but experience multiple relapses. Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor approved by the US Food and Drug Administration for relapsed MCL based on a clinical trial demonstrating an overall response rate of 81%. It provides a valuable new treatment option for MCL patients and is now being tested upfront.
Selo DaSilva