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Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG+ plasma cell persistence in the bone marrow.

Männe, Christian; Takaya, Akiko; Yamasaki, Yuzuru; Mursell, Mathias; Hojyo, Shintaro; Wu, Tsung-Yen; Sarkander, Jana; McGrath, Mairi A; Cornelis, Rebecca; Hahne, Stefanie; Cheng, Qingyu; Kawamoto, Tadafumi; Hiepe, Falk; Kaufmann, Stefan H E; Yamamoto, Tomoko; Radbruch, Andreas; Tokoyoda, Koji.
Proc Natl Acad Sci U S A; 116(15): 7425-7430, 2019 04 09.
Artigo em Inglês | MEDLINE | ID: mdl-30910977
Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient Salmonella induces high and lasting titers of specific and protective Salmonella-specific IgG and qualifies as an efficient vaccine against Salmonella A SiiE-derived peptide with homology to laminin ß1 is sufficient to ablate IgG-secreting plasma cells from the BM, identifying laminin ß1 as a component of niches for IgG-secreting plasma cells in the BM, and furthermore, qualifies it as a unique therapeutic option to selectively ablate IgG-secreting plasma cells in autoimmune diseases and multiple myeloma.
Selo DaSilva