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Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects: how far shall we wander?

Lu, Qin; Wang, Sheng-Ming; Liu, Yi-Xiao; Chen, Hong; Zhang, Rui; Zhang, Wen-Hui; Zou, Yuan-Yuan; Zhou, Jia-Wei; Guo, Xin-Yi; Zhang, Ying; Huang, Teng-Li; Liu, Yu-Hang; Zhang, Si-Qi; Yamanishi, Kyosuke; Yamanishi, Hiromichi; Higashino, Hideaki; Okamura, Haruki.
Acta Pharmacol Sin; 40(8): 1119-1126, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30760834
Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle modification. While most hypertension guidelines recommend moderate- to high-intensity exercise, we decided to explore a mild yet effective type of exercise to add to hypertension management, especially in populations with complications or frailty. After comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers (km) (3 km/h versus 6 km/h) in young, healthy volunteers, we delivered low-speed walking (low-intensity walking, 2.5 metabolic equivalents of task, METs) as exercise therapy in 42 prehypertensive and 43 hypertensive subjects. We found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects; these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine ß-endorphin output. Then we prescribed regular low-intensity walking with a target exercise dose (exercise volume) of 500-1000 METs·min/week (50-60 min/day and 5-7 times/week) in hypertensive subjects in addition to their daily activities. Regular low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two months. It is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.
Selo DaSilva