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Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females.

Ofori, Emmanuel K; Conde Alonso, Sonia; Correas-Gomez, Lorena; Carnero, Elvis A; Zwygart, Karin; Hugues, Henry; Bardy, Daniel; Hans, Didier; Dwyer, Andrew A; Amati, Francesca.
Clin Endocrinol (Oxf); 90(3): 433-439, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30575083


Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.


Observational, cross-sectional study of healthy, community dwelling postmenopausal women.PATIENTS AND MEASUREMENTS: Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry.


Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05).


Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.
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