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Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.

González-Herrera, Lizbeth; Zavala-Castro, Jorge; Ayala-Cáceres, Claudia; Pérez-Mendoza, Gerardo; López-González, María José; Pinto-Escalante, Doris; Canto-Cetina, Thelma; García-Escalante, María Guadalupe; Rubi-Castellanos, Rodrigo; Contreras-Capetillo, Silvina; Herrera-Sanchez, Fernando; Méndez-Domínguez, Nina; Alcocer-Gamboa, Alberto.
Am J Hum Biol; 31(1): e23192, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30537186

OBJECTIVES:

Genetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.

METHODS:

We included 318 school-aged children with obesity or overweight status (body mass index [BMI] >85th percentile) and 303 children with normal weight (BMI 15th-85th percentile). Genotyping was performed using real-time polymerase chain reaction (RT-PCR) with TaqMan probes. The cross-sectional study was carried out using univariate and multivariate logistic regression models adjusted for gender.

RESULTS:

FTO-SNP rs1421085 showed significant differences between children with obesity and children with normal weight for the heterozygous genotype (P = 0.003) and for allele frequencies (P = 0.023). Adjusting by gender, significant differences were found in frequencies of the hetezygous genotype of SNPs rs9939609 (P = 0.023) and rs1421085 (P = 0.003) as well as in allele frequencies (P = 0.042 and P = 0.013, respectively) between girls with obesity and girls without obesity. In contrast, SNP rs8057044 was significantly different only between heterozygous overweight versus normal weight boys (P = 0.035) and for the allele frequency of rs8057044 (P = 0.021). The mean relative CNV was significantly higher in male overweight children than in boys with normal weight (P = 0.000).

CONCLUSIONS:

The FTO SNP rs1421085 is a genetic factor associated with obesity in Mayan school-aged children. FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
Selo DaSilva