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Trained Immunity and Local Innate Immune Memory in the Lung.

Netea, Mihai G; Joosten, Leo A B.
Cell; 175(6): 1463-1465, 2018 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-30500533
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8+ lymphocytes initiating this process.
Selo DaSilva