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Stem Cells, Genome Editing, and the Path to Translational Medicine.

Soldner, Frank; Jaenisch, Rudolf.
Cell; 175(3): 615-632, 2018 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-30340033
The derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.
Selo DaSilva