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The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells.

Lepletier, Ailin; Lutzky, Viviana P; Mittal, Deepak; Stannard, Kimberley; Watkins, Thomas S; Ratnatunga, Champa N; Smith, Corey; McGuire, Helen M; Kemp, Roslyn A; Mukhopadhyay, Pamela; Waddell, Nicola; Smyth, Mark J; Dougall, William C; Miles, John J.
Immunol Cell Biol; 2018 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-30222899
CD96 has recently been shown to be a potent immune checkpoint molecule in mice, but a similar role in humans is not known. In this study, we provide a detailed map of CD96 expression across human lymphocyte lineages, the kinetics of CD96 regulation on T-cell activation and co-expression with other conventional and emerging immune checkpoint molecules. We show that CD96 is predominantly expressed by T cells and has a unique lymphocyte expression profile. CD96high T cells exhibited distinct effector functions on activation. Of note, CD96 expression was highly correlated with T-cell markers in primary and metastatic human tumors and was elevated on antigen-experienced T cells and tumor-infiltrating lymphocytes. Collectively, these data demonstrate that CD96 may be a promising immune checkpoint to enhance T-cell function against human cancer and infectious disease.
Selo DaSilva