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Genome-wide association study in Guillain-Barré syndrome.

Blum, Stefan; Ji, Ying; Pennisi, David; Li, Zhixiu; Leo, Paul; McCombe, Pamela; Brown, Matthew A.
J Neuroimmunol; 323: 109-114, 2018 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-30196823
Guillain-Barré syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.
Selo DaSilva