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Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline.

Raghu, Ganesh; Remy-Jardin, Martine; Myers, Jeffrey L; Richeldi, Luca; Ryerson, Christopher J; Lederer, David J; Behr, Juergen; Cottin, Vincent; Danoff, Sonye K; Morell, Ferran; Flaherty, Kevin R; Wells, Athol; Martinez, Fernando J; Azuma, Arata; Bice, Thomas J; Bouros, Demosthenes; Brown, Kevin K; Collard, Harold R; Duggal, Abhijit; Galvin, Liam; Inoue, Yoshikazu; Jenkins, R Gisli; Johkoh, Takeshi; Kazerooni, Ella A; Kitaichi, Masanori; Knight, Shandra L; Mansour, George; Nicholson, Andrew G; Pipavath, Sudhakar N J; Buendía-Roldán, Ivette; Selman, Moisés; Travis, William D; Walsh, Simon; Wilson, Kevin C.
Am J Respir Crit Care Med; 198(5): e44-e68, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-30168753


This document provides clinical recommendations for the diagnosis of idiopathic pulmonary fibrosis (IPF). It represents a collaborative effort between the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society.


The evidence syntheses were discussed and recommendations formulated by a multidisciplinary committee of IPF experts. The evidence was appraised and recommendations were formulated, written, and graded using the Grading of Recommendations, Assessment, Development, and Evaluation approach.


The guideline panel updated the diagnostic criteria for IPF. Previously defined patterns of usual interstitial pneumonia (UIP) were refined to patterns of UIP, probable UIP, indeterminate, and alternate diagnosis. For patients with newly detected interstitial lung disease (ILD) who have a high-resolution computed tomography scan pattern of probable UIP, indeterminate, or an alternative diagnosis, conditional recommendations were made for performing BAL and surgical lung biopsy; because of lack of evidence, no recommendation was made for or against performing transbronchial lung biopsy or lung cryobiopsy. In contrast, for patients with newly detected ILD who have a high-resolution computed tomography scan pattern of UIP, strong recommendations were made against performing surgical lung biopsy, transbronchial lung biopsy, and lung cryobiopsy, and a conditional recommendation was made against performing BAL. Additional recommendations included a conditional recommendation for multidisciplinary discussion and a strong recommendation against measurement of serum biomarkers for the sole purpose of distinguishing IPF from other ILDs.


The guideline panel provided recommendations related to the diagnosis of IPF.
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