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Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil.

Amaral, Carolina Dourado; Costa, Galileu Barbosa; de Souza, William Marciel; Alves, Pedro Augusto; Borges, Iara Apolinário; Tolardo, Aline Lavado; Romeiro, Marília Farignoli; Drumond, Betânia Paiva; Abrahão, Jônatas Santos; Kroon, Erna Geessien; Paglia, Adriano Pereira; Figueiredo, Luiz Tadeu Moraes; de Souza Trindade, Giliane.
Ecohealth; 15(3): 577-589, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30105563
New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012-2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.
Selo DaSilva