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Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.

Yao, Siyuan; Yagi, Shintaro; Nagao, Miki; Uozumi, Ryuji; Iida, Taku; Iwamura, Sena; Miyachi, Yosuke; Shirai, Hisaya; Kobayashi, Atsushi; Okumura, Shinya; Hamaguchi, Yuhei; Masano, Yuuki; Kaido, Toshimi; Okajima, Hideaki; Uemoto, Shinji.
Eur J Clin Microbiol Infect Dis; 37(10): 1973-1982, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30039291
The interpretation of bacterial cholangitis after liver transplantation (LT) remains vague, because the presence of bacteria in bile, namely bacteriobilia, does not necessarily indicate an active infection. We investigated the association between post-LT bacterial cholangitis and a variety of short- and long-term outcomes. Two-hundred-seventy-four primary adult-to-adult living donor LT recipients from 2008 to 2016 were divided into three groups according the presence or absence of bacteriobilia and clinical symptoms: (1) no bacteriobilia (N group), (2) asymptomatic bacteriobilia (B group), and (3) cholangitis (C group). The number of patients was by group: N, 161; B, 64; and C, 49. Donor age ≥ 45 years (p = 0.012), choledochojejunostomy (p < 0.001), and post-LT portal hypertension (p = 0.023) were independent risk factors for developing cholangitis. Survival analysis revealed that the C group had significantly worse short- and long-term graft survival. The C group was associated with an increased incidence of early graft loss (EGL) (p < 0.001). While the frequency of readmission for recurrent cholangitis was significantly higher in both the B and C groups (p < 0.001), late graft loss (LGL) due to chronic cholangitis was only commonly observed in the C group (p = 0.002). Post-LT cholangitis could result in not only EGL but also chronic cholangitis and associated LGL.
Selo DaSilva