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Genetic diversity of bat orthohepadnaviruses in China and a proposed new nomenclature.

Yang, Ling'en; Wu, Jianmin; Hu, Tingsong; Qin, Shaomin; Deng, Bo; Liu, Jinfeng; Zhang, Fuqiang; He, Biao; Tu, Changchun.
Infect Genet Evol; 63: 135-143, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29842981
The orthohepadnaviruses, which include the major human pathogen hepatitis B virus, exist in a wide range of hosts. Since 2013, a large group of orthohepadnaviruses has been identified in bats worldwide and classified as 4 species within the genus Orthohepadnavirus. To further investigate orthohepadnaviruses in the Chinese bat population, 554 archived bat samples from 20 colonies covering 3 southern provinces were screened with results showing that 9 (1.6%) were positive. A systematic phylogenetic analysis has indicated the need for a new nomenclature for bat hepatitis B virus-like viruses BtHBV, with the addition of 3 new species, one being divided into 6 genotypes. Viruses identified here shared 9.0-19.2% full genome divergence and classified into 3 different genotypes. This study illustrates the genetic diversity of orthohepadnaviruses in the Chinese bat population, and emphasizes need for further investigation of their public health significance.
Selo DaSilva