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Eculizumab reversed severe distal ischemic syndrome and glomerulonephritis with isolated C3 deposits associated with anti-factor H autoantibodies: a case report.

Deshayes, Samuel; Martin Silva, Nicolas; Chatelet, Valérie; Chantepie, Sylvain; Le Quintrec, Moglie; Comoz, François; Bridoux, Frank; Dragon-Durey, Marie-Agnès; Aouba, Achille.
Clin Rheumatol; 37(4): 1119-1122, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29516279
B-cell clones can produce a monoclonal immunoglobulin, which may be responsible for visceral involvements. Kidney involvement is frequent, affecting 20 to 50% of patients with multiple myeloma. One mechanism underlying this involvement is a dysregulation of the complement alternative pathway, leading to C3 glomerulopathies. We report a patient who had a multiple myeloma, C3 glomerulopathy related to factor H autoantibody, and digital ischemia, who was treated successfully with eculizumab, an anti-complement therapy, without any relapse in 2 years of follow-up.
Selo DaSilva