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Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors.

Duskova, Katerina; Vesely, Stepan; DO Carmo Silva, Joana; Cernei, Natalia; Zitka, Ondrej; Heger, Zbynek; Adam, Vojtech; Havlova, Klara; Babjuk, Marek.
In Vivo; 32(2): 425-429, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29475932

BACKGROUND:

Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors.

MATERIALS AND METHODS:

Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21).

RESULTS:

In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma.

CONCLUSION:

Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.
Selo DaSilva