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Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital.

Huang, Bin; He, Yuting; Ma, Xingyan; Cai, Renxin; Zeng, Jianming; Lu, Yang; Zhang, Weizheng; Lan, Kai; E, Sunmei; Tang, Yi-Wei; Kreiswirth, Barry N; Chen, Cha; Chen, Liang.
Antimicrob Agents Chemother; 62(5)2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29463536
Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.
Selo DaSilva