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Comparison of In-hospital Outcomes Between Transcatheter and Surgical Aortic Valve Replacement in Patients with Aortic Valve Stenosis: A Retrospective Cohort Study Using Administrative Data.

Umegaki, Takeshi; Kunisawa, Susumu; Nakajima, Yasufumi; Kamibayashi, Takahiko; Fushimi, Kiyohide; Imanaka, Yuichi.
J Cardiothorac Vasc Anesth; 32(3): 1281-1288, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29422279

OBJECTIVE:

The number of surgeries for valvular heart disease performed in Japan has greatly increased over the past decade, and surgical aortic valve replacements (SAVR) constitute the vast majority of aortic valve replacement procedures. Although transcatheter aortic valve implantation (TAVI) was recently introduced, studies have yet to compare the clinical outcomes between TAVI and SAVR in the Japanese healthcare setting. This study aimed to compare in-hospital outcomes between TAVI and SAVR using a multicenter administrative database.

DESIGN:

Retrospective cohort study.

SETTING:

Acute care hospitals in Japan.

PARTICIPANTS:

A total of 16,775 patients diagnosed with aortic valve stenosis.

INTERVENTIONS:

None. MEASUREMENTS AND MAIN

RESULTS:

The main study outcome measure was in-hospital mortality. Based on multiple logistic regression analysis using inverse probability of treatment weighting, the odds ratio of in-hospital mortality for TAVI (relative to SAVR) was calculated to be 0.36 (95% confidence intervals 0.13-0.98; p = 0.04). In patients aged 80 years or older, the odds ratio was even lower at 0.34 (95% confidence intervals 0.15-0.73; p < 0.01). In addition, the incidences of reoperations, hemorrhagic complications, cardiac tamponade, and postoperative infections were significantly higher in the SAVR patients.

CONCLUSIONS:

This large-scale multicenter comparative analysis of TAVI and SAVR in Japan indicated that TAVI produced better clinical outcomes in patients with aortic valve stenosis. The improved outcomes were particularly notable in patients aged 80 years or older.
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