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Transcoronary cell infusion with the stop-flow technique in children with single-ventricle physiology.

Eitoku, Takahiro; Baba, Kenji; Kondou, Maiko; Kurita, Yoshihiko; Fukushima, Yousuke; Hirai, Kenta; Ohtsuki, Shinichi; Ishigami, Shuta; Sano, Shunji; Oh, Hidemasa.
Pediatr Int; 60(3): 240-246, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29266671

BACKGROUND:

Almost all reports on cardiac regeneration therapy have referred to adults, and only a few have focused on transcoronary infusion of cardiac progenitor cells using the stop-flow technique in children.

METHODS:

Intracoronary autologous cardiosphere-derived cell (CDC) transfer was conducted at Okayama University as a phase 1 clinical trial for seven patients with hypoplastic left heart syndrome between January 2011 and December 2012, and as a phase 2 clinical trial for 34 patients with single-ventricle physiology between July 2013 and March 2015.

RESULTS:

A total of 41 patients with single-ventricle physiology underwent transcoronary infusion of CDC with the stop-flow technique. The median age was 33 months (range, 5-70 months) and the median weight was 10.1 kg (range, 4.1-16.0 kg). Transient adverse events occurred during the procedure, including ST-segment elevation or depression, hypotension, bradycardia, and coronary artery vasospasm. All patients completely recovered. There were no major procedure-related adverse events. In this study, transcoronary infusion of CDC using the stop-flow technique was successfully completed in all patients.

CONCLUSION:

Transcoronary infusion of CDC using the stop-flow technique in children is a feasible and safe procedure.
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