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Characterization of KPC-Encoding Plasmids from Enterobacteriaceae Isolated in a Czech Hospital.

Kukla, Rudolf; Chudejova, Katerina; Papagiannitsis, Costas C; Medvecky, Matej; Habalova, Katerina; Hobzova, Lenka; Bolehovska, Radka; Pliskova, Lenka; Hrabak, Jaroslav; Zemlickova, Helena.
Artigo em Inglês | MEDLINE | ID: mdl-29263065
Ten Enterobacteriaceae isolates collected in a Czech hospital carried blaKPC-positive plasmids of different sizes (∼30, ∼45, and ∼80 kb). Sequencing revealed three types of plasmids (A to C) with the Tn4401a transposon. Type A plasmids comprised an IncR backbone and a KPC-2-encoding multidrug resistance (MDR) region. Type B plasmids were derivatives of type A plasmids carrying an IncN3-like segment, while type C plasmids were IncP6 plasmids sharing the same KPC-2-encoding MDR region with type A and B plasmids.
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