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Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study.

Kingsley, Samantha L; Kelsey, Karl T; Butler, Rondi; Chen, Aimin; Eliot, Melissa N; Romano, Megan E; Houseman, Andres; Koestler, Devin C; Lanphear, Bruce P; Yolton, Kimberly; Braun, Joseph M.
Environ Res; 158: 174-178, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28645023
Perfluorooctanoic acid (PFOA), a perfluoroalkyl substance, is commonly detected in the serum of pregnant women and may impact fetal development via epigenetic re-programming. In a pilot study, we explored associations between serum PFOA concentrations during pregnancy and offspring peripheral leukocyte DNA methylation at delivery in women with high (n = 22, range: 12-26ng/mL) and low (n = 22, range: 1.1-3.1ng/mL) PFOA concentrations. After adjusting for cell type, child sex, and income, we did not find differences in CpG methylation in the two exposure groups that reached epigenome-wide significance. Among the 20 CpGs with the lowest p-values we found that seven CpG sites in three genes differed by exposure status. In a confirmatory cluster analysis, these 20 CpGs clustered into two groups that perfectly identified exposure status. Future studies with larger sample sizes should confirm these findings and determine if PFOA-associated changes in DNA methylation underlie potential health effects of PFOA.
Selo DaSilva