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[Research progress on the animal models and treatment strategies of diabetic foot ulcer].

Gao, Siqian; Shen, Yongmei; Geng, Funeng; Li, Yanhua; Gao, Jianqing.
Zhejiang Da Xue Xue Bao Yi Xue Ban; 46(1): 97-105, 2017 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-28436638
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
Selo DaSilva