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Emerging RNA editing biomarkers will foster drug development.

van der Laan, Siem; Salvetat, Nicolas; Weissmann, Dinah; Molina, Franck.
Drug Discov Today; 22(7): 1056-1063, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28188894
Unanticipated adverse drug reactions (ADRs) on the central nervous system are a major cause of clinical attrition and market withdrawal. Current practices for their prospective assessment still lean on extensive analysis of rodent behaviour despite their highly controversial predictive value. Human-derived in vitro models that objectively quantify mechanism-related biomarkers can greatly contribute to better ADR prediction at early developmental stages. Adenosine-to-inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease. Robust solutions based on NGS-based quantification of RNA editing biomarkers have emerged to predict the likelihood of treatment-related suicidal ideation and behaviour allowing cost-effective high-throughput drug screening as a strategy for risk mitigation.
Selo DaSilva