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Biodegradation and tissue integration of various polyethylene glycol matrices: a comparative study in rabbits.

Thoma, Daniel S; Weber, Franz E; Bienz, Stefan P; Ge, Yanjun; Hämmerle, Christoph H F; Jung, Ronald E.
Clin Oral Implants Res; 28(11): e244-e251, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28111809


To test whether or not chemical and/or physical modifications of polyethylene glycol (PEG) hydrogels influence degradation time, matrix/membrane stability, and integration into surrounding hard and soft tissues. MATERIAL AND


In 28 rabbits, six treatment modalities were randomly applied to six sites on the rabbit skull a dense network PEG hydrogel (PEG HD), a medium-dense network PEG hydrogel (PEG MD), a medium-dense network PEG hydrogel modified with an RGD sequence (PEG MD/RGD), a medium-dense network PEG hydrogel modified with RGD with reduced carboxymethyl cellulose (PEG MD/RGD_LV), a loose network PEG hydrogel modified with RGD (PEG LD/RGD), and a collagen membrane (BG). Descriptive histology and histomorphometry were performed at 1, 2, 4, and 6 weeks.


PEG HD revealed the highest percentage of residual matrix at all time points starting with 47.2% (95% CI 32.8-63.8%) at 1 week and ending with 23.4% (95% CI 10.3-49.8%) at 6 weeks. The hydrogel with the loosest network (PEG LD/RGD) was stable the first 2 weeks and then degraded continuously with a final area of 8.3% (95% CI 3.2-21.2%). PEG HD was the most stable and densely stained membrane, whereas PEG MD and PEG LD matrices integrated faster, but started to degrade to a higher degree between 2 and 4 weeks. PEG MD degradation was dependent on the addition of RGD and the amount of CMC.


Chemical and/or physical modifications of PEG hydrogels influenced matrix stability. PEG MD/RGD demonstrated an optimal balance between degradation time and integration into the surrounding soft and hard tissues.
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