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Un cas de carcinome urothélial avec différenciation trophoblastique et revue de la littérature. / [A case of urothelial carcinoma with trophoblastic differentiation and review of the literature].

Cazorla, Arnault; Sibony, Mathilde; Pedron, Philippe; Munz-Beaugrand, Cécile.
Ann Pathol; 36(5): 347-350, 2016 Oct.
Artigo em Francês | MEDLINE | ID: mdl-27639773
We report the case of a 43-year-old woman, who was admitted for intense pelvic pains. Biological investigations showed an increase of ß-HCG level. The abdomino-pelvic computed tomography revealed a voluminous mass infiltrating the bladder. A transurethral resection was performed. The histopathological examination evidenced an invasion of the bladder by a massive carcinomatous proliferation composed of clear epithelial cells with in some places syncytiotrophoblastic cells and rarely cytotrophoblastic cells. Immunohistochemical analyses revealed a staining of GATA-3 by the two components, an expression of p63 by the clear cell urothelial component and the immunoreactivity of ß-HCG by the trophoblastic component. Ki-67 labeling index was very high. The diagnosis of mixt urothelial carcinoma with clear cells and trophoblastic differentiation was proposed. This is a rare difficult histopathological diagnosis which should be known by pathologists. It is correlated to a poor clinical outcome with a high tendency to lymph node or visceral metastases.
Selo DaSilva