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Look Out Autophagy, Ubiquilin UPS Its Game.

Brown, Rachel; Kaganovich, Daniel.
Cell; 166(4): 797-799, 2016 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-27518558
Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.
Selo DaSilva