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Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization.

Li, Ertong; Hu, Zhiyuan; Song, Lina; Yu, Wenquan; Chang, Junbiao.
Chemistry; 22(31): 11022-7, 2016 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-27355559
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclization. This transition-metal-free synthetic process is broadly applicable to a variety of aromatic, aliphatic, and α,ß-unsaturated aldehydes, and can be conveniently conducted on the gram scale.
Selo DaSilva