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Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I2 /KI-Mediated Oxidative Cyclization.

Tian, Xianhai; Song, Lina; Wang, Manman; Lv, Zhigang; Wu, Jie; Yu, Wenquan; Chang, Junbiao.
Chemistry; 22(22): 7617-22, 2016 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-27112949
A novel and practical strategy for the construction of imidazo[1,2-a]pyridin-2-amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2 /KI-mediated oxidative C-N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2-amino substituted imidazo[1,2-a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.
Selo DaSilva