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Emerging Diversity of the Cobalamin-Dependent Methyltransferases Involving Radical-Based Mechanisms.

Ding, Wei; Li, Qien; Jia, Youli; Ji, Xinjian; Qianzhu, Haocheng; Zhang, Qi.
Chembiochem; 17(13): 1191-7, 2016 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-27028019
Cobalamins comprise a group of cobalt-containing organometallic cofactors that play important roles in cellular metabolism. Although many cobalamin-dependent methyltransferases (e.g., methionine synthase MetH) have been extensively studied, a new group of methyltransferases that are cobalamin-dependent and utilize radical chemistry in catalysis is just beginning to be appreciated. In this Concept article, we summarize recent advances in the understanding of the radical-based and cobalamin-dependent methyltransferases and discuss the functional and mechanistic diversity of this emerging class of enzymes.
Selo DaSilva