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Germinal Centers: Gaining Strength from the Dark Side.

Cyster, Jason G.
Immunity; 43(6): 1026-8, 2015 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-26682975
Germinal center B cells exist in two conditions, a dark zone state and a light zone state. Two studies in this issue (Dominguez-Sola et al., 2015; Sander et al., 2015) report that Foxo1 deficiency causes an almost complete loss of dark zone cells and an inability to undergo robust antibody affinity maturation.
Selo DaSilva