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Diagnosis and management of aspergillosis in the Netherlands: a national survey.

Lestrade, Pieter P A; Meis, Jacques F; Arends, Jan P; van der Beek, Martha T; de Brauwer, Els; van Dijk, Karin; de Greeff, Sabine C; Haas, Pieter-Jan; Hodiamont, Caspar J; Kuijper, Ed J; Leenstra, Tjalling; Muller, Anouk E; Oude Lashof, Astrid M L; Rijnders, Bart J; Roelofsen, Eveline; Rozemeijer, Wouter; Tersmette, Mathijs; Terveer, Elizabeth M; Verduin, Cees M; Wolfhagen, Maurice J H M; Melchers, Willem J G; Verweij, Paul E.
Mycoses; 59(2): 101-7, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26648179
A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.
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