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Design and Analysis of Single-Cell Sequencing Experiments.

Grün, Dominic; van Oudenaarden, Alexander.
Cell; 163(4): 799-810, 2015 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-26544934
Recent advances in single-cell sequencing hold great potential for exploring biological systems with unprecedented resolution. Sequencing the genome of individual cells can reveal somatic mutations and allows the investigation of clonal dynamics. Single-cell transcriptome sequencing can elucidate the cell type composition of a sample. However, single-cell sequencing comes with major technical challenges and yields complex data output. In this Primer, we provide an overview of available methods and discuss experimental design and single-cell data analysis. We hope that these guidelines will enable a growing number of researchers to leverage the power of single-cell sequencing.
Selo DaSilva