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Primary immunodeficiency update: Part I. Syndromes associated with eczematous dermatitis.

Pichard, Dominique C; Freeman, Alexandra F; Cowen, Edward W.
J Am Acad Dermatol; 73(3): 355-64; quiz 365-6, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26282794
In the past decade, the availability of powerful molecular techniques has accelerated the pace of discovery of several new primary immunodeficiencies (PIDs) and revealed the biologic basis of other established PIDs. These genetic advances, in turn, have facilitated more precise phenotyping of associated skin and systemic manifestations and provide a unique opportunity to better understand the complex human immunologic response. These continuing medical education articles will provide an update of recent advances in PIDs that may be encountered by dermatologists through their association with eczematous dermatitis, infectious, and non-infectious cutaneous manifestations. Part I will discuss new primary immunodeficiencies that have an eczematous dermatitis. Part II will focus on primary immunodeficiencies that greatly increase susceptibility to fungal infection and the noninfectious presentations of PIDs.
Selo DaSilva