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The zDHHC family of S-acyltransferases.

Lemonidis, Kimon; Werno, Martin W; Greaves, Jennifer; Diez-Ardanuy, Cinta; Sanchez-Perez, Maria C; Salaun, Christine; Thomson, David M; Chamberlain, Luke H.
Biochem Soc Trans; 43(2): 217-21, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25849920
The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.
Selo DaSilva