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Bacillus Calmette-Guerin injections for melanoma immunotherapy: potential for a false-positive PET/CT.

Sogge, Steven M; Fotos, Joseph S; Tulchinsky, Mark.
Clin Nucl Med; 40(4): 368-9, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25674877
An 82-year-old woman presented for routine follow-up PET/CT after undergoing local melanoma resection in the left lower leg, isolated limb infusion chemotherapy, and immunomodulation therapy with Bacillus Calmette-Guérin (BCG) vaccine. Symmetric, bilateral, moderately intense FDG avid axillary and inguinal cutaneous nodules were observed that were new from the prior PET-CT. The patient had developed skin lesions at the BCG injection sites several months before the study. The case raises awareness to PET/CT appearance of local inflammatory response to BCG injection, which could be mistaken by an unaware reader for recurrent melanoma.
Selo DaSilva