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SnapShot: GPCR-Ligand Interactions.

Ghosh, Eshan; Nidhi, Kumari; Shukla, Arun K.
Cell; 159(7): 1712, 1712.e1, 2014 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-25525884
G-protein-coupled receptors enable cells to recognize numerous external stimuli and to transmit corresponding signals across the plasma membrane to trigger appropriate cellular responses. Crystal structures of a number of these receptors have now been determined in inactive and active conformations bound to chemically and functionally distinct ligands. These crystal structures illustrate overall receptor organization and atomic details of ligand-receptor interactions.
Selo DaSilva