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[Research progress of Tbx3 in cardiac biological pacemaker].

Li, Yong; Li, Bingong.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 31(4): 923-6, 2014 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-25464814
The early cardiac biological pacemaker studies were mostly around HCN channel, and how to build a biological pacemaker through the enhanced If current. In recent years, however, people found that the genes of Tbx3 could play an important role in the development of cardiac conduction system, especially in processes of the maturity of the sinoatrial node and maintenance of its function. And the Tbx3 can further optimize the biological pacemaker. Therefore, it could be a new therapeutic focus in biological pacemaker and treatment of cardiac conduction system disease. This paper summarizes some of the latest research progress of the Tbx3 in biological pacemaker in recent years. We hope that this review could provide theoretical basis for the clinical applications of Tbx3.
Selo DaSilva