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Genetic variation meets replication origins.

Hause, Ronald J; Shendure, Jay.
Cell; 159(5): 973-974, 2014 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-25416936
Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.
Selo DaSilva