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Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation.

Lippert, Rainer; Vojnovic, Sandra; Mitrovic, Aleksandra; Jux, Norbert; Ivanovic-Burmazovic, Ivana; Vasiljevic, Branka; Stankovic, Nada.
Bioorg Med Chem Lett; 24(15): 3506-11, 2014 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-24929472
Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C. albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 µg/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C. albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 µg/mL, however it does not cause hemolysis in concentrations of up to 50 µg/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals.
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