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Satellite glial cells in dorsal root ganglia are activated in experimental autoimmune encephalomyelitis.

Warwick, Rebekah A; Ledgerwood, Craig J; Brenner, Talma; Hanani, Menachem.
Neurosci Lett; 569: 59-62, 2014 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-24686185
Pain is a serious and common problem with patients suffering from multiple sclerosis (MS). Very little has been done to investigate the peripheral mechanisms of pain in MS. Here we used a mouse model of experimental autoimmune encephalomyelitis (EAE) to investigate the possible contribution of satellite glial cells (SGCs) to pain in MS. EAE mice had reduced pain thresholds 10 days after disease induction. We examined dorsal root ganglia and found increased expression of glial fibrillary acidic protein in SGCs, a marker of SGC activation, and increased coupling among SGCs, a known component of activated SGCs. Activated SGCs have previously been shown to contribute to pain in other classical neuropathic pain models, suggesting that pain in multiple sclerosis has a peripheral component.
Selo DaSilva