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Environments of B cell development.

Tsuneto, Motokazu; Kajikhina, Ekaterina; Seiler, Katharina; Reimer, Andreas; Tornack, Julia; Bouquet, Corinne; Simmons, Szandor; Knoll, Marko; Wolf, Ingrid; Tokoyoda, Koji; Hauser, Anja; Hara, Takahiro; Tani-ichi, Shizue; Ikuta, Koichi; Grün, Joachim R; Grützkau, Andreas; Engels, Niklas; Wienands, Jürgen; Yanagisawa, Yuki; Ohnishi, Kazuo; Melchers, Fritz.
Immunol Lett; 157(1-2): 60-3, 2014 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24284375
B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
Selo DaSilva