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How to understand the association between cystatin C levels and cardiovascular disease: Imbalance, counterbalance, or consequence?

Salgado, João Victor; Souza, Francival Leite; Salgado, Bernardete Jorge.
J Cardiol; 62(6): 331-5, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23849291
The association of cystatin C with renal function has been studied for more than 25 years. Cystatin C has been described to have a better diagnostic performance than creatinine to assess renal function, particularly to detect small reductions in glomerular filtration rate. Recently, cystatin C has emerged as a strong predictor of incident or recurrent cardiovascular events and adverse outcomes in patients without kidney disease. Furthermore, it has been suggested that cystatin C concentrations are directly related to both inflammation and atherosclerosis. Nevertheless, the link between inflammation, atherogenesis, cardiovascular risk, and cystatin C is still poorly understood. This brief report discusses recent data, contrasting findings and possible mechanisms involved in this interaction.
Selo DaSilva