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[Glycosylated hemoglobin A1c for the diagnosis of diabetes mellitus: a meta-analysis].

Tang, Song-tao; Zhang, Qiu; Wang, Chang-jiang; Tang, Hai-qin; Wu, Tai-xiang.
Zhonghua Nei Ke Za Zhi; 52(1): 21-5, 2013 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-23710810


To assess the diagnostic value of glycosylated hemoglobin A1c (HbA1c) ≥ 6.5% for diabetes in Chinese adults with oral glucose tolerance test (OGTT) as the reference standard.


Major databases were searched to get all diagnostic tests with HbA1c ≥ 6.5% for diabetes in Chinese adults. QUADAS items were used to evaluate the quality of the eligible studies. Meta-disc software was used to perform comprehensive quantitative assessment for all included studies and summary ROC (SROC) curve were drawn.


A total of 11 studies were included. The outcomes of the diagnostic value with HbA1c ≥ 6.5% were as the following pooled sensitivity 0.62 (95%CI 0.60 - 0.64), pooled specificity 0.96 (95%CI 0.95 - 0.96), diagnostic odds ratio (DOR) 40.25 (95%CI 20.79 - 77.95) and AUCSROC 0.7702 (sx = 0.0636).


The diagnostic specificity is pretty high for the diagnostic test with HbA1c ≥ 6.5%, while sensitivity is low. Combination of HbA1c and glucose tests is needed to reduce the missed diagnosis rate.
Selo DaSilva