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The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: a randomized triple-masked controlled trial.

Safavi, Morteza; Farajian, Sanam; Kelishadi, Roya; Mirlohi, Maryam; Hashemipour, Mahin.
Int J Food Sci Nutr; 64(6): 687-93, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23477506
Recent studies have suggested some beneficial effects of probiotics on controlling excess weight in adults; such experience is limited in the pediatric age group. This study aimed to assess the anti-obesity and lipid-lowering effects of a synbiotic supplement among children and adolescents. We conducted a randomized triple-masked controlled trial among 70 participants aged 6-18 years with body mass index (BMI) equal or higher than 85th percentile. They were randomly assigned to two groups of equal number to receive synbiotic or placebo for 8 weeks. At the end of the trial, decrease in BMI Z-score, waist circumference, and waist-to-hip ratio were significantly higher in the synbiotic group than in the placebo group. Likewise, synbiotic group had significant decrease in serum triglycerides, total- and low density lipoprotein-cholesterol levels. The beneficial effects of a synbiotic supplement on controlling excess weight and some cardio-metabolic risk factors among children and adolescents can be considered in clinical practice.
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