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The origins and drivers of insulin resistance.

Johnson, Andrew M F; Olefsky, Jerrold M.
Cell; 152(4): 673-84, 2013 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-23415219
Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.
Selo DaSilva